Epigenetic Cooperation Norrland
The focus of the research group is on gene regulation and the function of the noncoding genome in metabolic diseases and during embryonic development.
We are interested in how the reprogramming of regulatory regions and topological changes in 3D chromatin organization determine gene dysregulation in glioblastoma.
Our research focuses on understanding the molecular mechanisms of epigenetic regulation by Polycomb and Trithorax proteins.
Our main interest is to decipher novel epigenetic and epitranscriptomic mechanisms affecting global gene expression and their implication in cell fate and cancer initiation and progression with a focus on breast cancer. We aim to elucidate the function of RNA modification, specifically adenosine methylation, and their crosstalk with other epigenetic marks, using stem cells and breast cancer cells, as physiological and pathological models.
Our focus is on the application of methods from theoretical physics to understand the dynamics of epigenetic memory and 3D topology of the epigenome.
We are interested in chromosome-wide gene regulatory mechanisms with focus on (1) deciphering the targeting mechanisms used by chromosome-wide gene regulatory complexes in particular and epigenetic regulators in general, (2) delineating the mechanisms for coordinated chromosome-wide gene regulation and (3) understanding the evolution of chromosome-wide gene targeting and regulation, sex-chromosomes and the role of heterochromatin and non-coding RNA in these processes.
The focus of the research group is to study the relevance of DNA methylation as a prognostic biomarker in childhood and adult hematological malignancies. By analyzing the biology behind methylation subgroups, we aim at identifying new potential targets for therapy.
EPICON